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Impact statement This study is the first to incorporate disease-specific, diabetic macrophages into a three-dimensional (3D) model of human skin. We show how to fabricate skin that incorporates macrophages with disease-specific fibroblasts to guide macrophage polarization. We also show that monocytes from diabetic patients can differentiate into macrophages directly in this skin disease model, and that they secrete a cytokine profile mimicking the proinflammatory M1 phenotype seen in diabetic foot ulcers. The data presented here indicate

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What is an Upgrade Item in Genshin Impact? Upgrade items are special items that can assist certain Pokemon evolve. They are obtained by spinning Pokestop photo discs and are sometimes used as rewards during events related to evolution. They can be incorporated into armor, weapons trinkets, weapons, or gathering tools to giv