What is Zopiclone

Zopiclone, available under the brand name Imovane, is a nonbenzodiazepine or Z-class medication used to treat insomnia in patients. Nonbenzodiazepines are new-generation hypnotics that exhibit similar mechanisms of action and pharmacodynamics but with a different molecular structure and shorter half-life, because of which they have a safer profile. Zopiclone is used in the short-term treatment of insomnia to improve sleep quality. Off-label, it is used in SWSD workers in initiating daytime sleep and as a part of cognitive behavior therapy for treating psychiatric issues.

What does Zopiclone do to the brain?

As a part of its mechanism of action, Buy Zopiclone UK binds to the benzodiazepine receptor complex in the CNS and modulates the GABA Z receptors chloride channel macromolecular complex. The effect of the medication on the GABA-containing receptors increases the inhibitory effects of GABA and subsequent sedation and relaxation of the individual. The action of Zopiclone on the alpha1 and alpha2 receptors brings out its anxiolytic effects, and the alpha three and alpha four receptors bring out its sedative effects.

Studies of Zopiclone in classical psycho-pharmacological tests, in comparison with benzodiazepines and barbiturates, have shown that the medication exhibits five main types of activity considered as characteristic of the pharmacological profile of benzos and partly of that of barbiturates i.e. anticonvulsant, myorelaxant, anti-aggressive, sedative-hypnotic and anti-conflict. but zopiclone has a safer profile than that of barbiturates and benzodiazepines. Animal electrophysiological studies have shown that zopiclone induces modifications in sleep-wakefulness patterns, close to those observed with benzodiazepines, especially with nitrazepam. Moreover, zopiclone increases the threshold for arousal by reticular formation stimulation, rather more than nitrazepam, but with a shorter duration of action.

The hypnotic efficacy of zopiclone administered as single oral doses has been demonstrated in patients undergoing next-day surgery and in patients with insomnia, and these studies have established an optimal dose of 7.5mg for elderly patients. Zopiclone causes minimal impairment to psychomotor performance and mental alertness the morning after night-time administration. The drug is generally well tolerated by patients of all ages. Studies have further proved that a short-term course of a standard 7.5 mg dose of nightly zopiclone does not worsen AHI, hypoxemia, daytime sleepiness, or morning alertness in individuals with OSA and is safe to be used in OSA conditions with caution.

Why should Zopiclone be used with caution?

Use of Zopiclone can lead to side effects in the form of nausea, gastrointestinal upset, excessive daytime drowsiness, diarrhea, rashes, and abdominal pain normally and occasionally increase in severity leading to, convulsions, seizures, loss of consciousness, and anaphylactic reactions. Being a short-term medication, using Zopiclone for prolonged periods can result in increased dependence even on the medication and make a withdrawal a challenging process. The withdrawal symptoms last for 5-14 days, gradually decreasing intensity before weaning off altogether. Still, while wearing off, thy can cause body spasms, seizures, insomnia, delirium, anxiety, drug cravings, irritability, depression, confusion, and hallucinations that can prove life-threatening to the patient. To stay on the safe side, Zopiclone should be used with caution and its use tapered off after its short-term use for the safety of the patient.

Before you Buy

There are a few things that you should keep in mind when you are buying zopiclone. First, make sure that you buy the correct dosage. Zopiclone comes in 3.75 mg, 7.5 mg, and 15 mg tablets. The correct dosage will depend on your individual needs and medical condition. Second, make sure that you buy zopiclone from a reputable source. There are many websites that sell zopiclone, but not all of them are reliable. You should only buy zopiclone from a website that is approved by the FDA or another regulatory body. Third, make sure to read the instructions carefully before taking zopiclone.