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The treating BRAFV600-mutated CRC is still a challenge when it comes to clinicians, mainly due to poor people survival results acquired with standard chemotherapy regimens. In the last few years, two novel treatment techniques have actually supplied remarkable alterations in the treatment of this unique patient subgroup. The first strategy has included targeted therapies directed against BRAF and MEK, with assistance from the epidermal growth element receptor (EGFR) blockade. The