https://www.selleckchem.com/pr....oducts/gsk2636771.ht
We identified 48 differentially methylated CpGs sites, of which 33 were hypomethylated. Of these, sixteen-CpG based MRS that was associated with CRC risk (OR = 2.68, 95% CI 2.13, 3.38, P 0.0001) was constructed. This association is confirmed in the testing dataset (OR = 2.02, 95% CI 1.48, 2.74, P 0.0001) and persisted in both males and females, younger and older subjects, short and long time-to-diagnosis. The MRS also predicted CRC with AUC 0.82 (95% CI 0.76, 0.88), indicating high accuracy. Our study has identified a novel
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