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The high expression of sonic hedgehog ligand (SHh) is closely correlated to the metastasis, drug resistance and poor prognosis of hepatocellular carcinoma (HCC). Therefore, sensitive, specific and efficient detection methods for SHh are needed for the early diagnosis and assessment of prognosis. Herein, an aptamer, AP32 that specifically binds to SHh (KD = 25.7 ± 4.1 nM) was obtained by SELEX technology with further optimization. In vivo experiments confirmed that AP32 has the potential to be an imaging probe for Huh-7 cell-derived xeno

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How to Find an Affordable Double Mattress A restful night's sleep is dependent on a great mattress--but it doesn't need to cost a lot. A lot of affordable mattresses are made of high-quality materials and are backed by reliable trials and warranties. The best way to find a mattress that is affordable is to go to sleep stores that specialize in mattresses and during sales and holidays (like the sales in winter). But, you can also get a great deal buying value models. Size A double mattress is 38 inches