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BACKGROUND Little data exist on the pathogenic mutations of LDL receptor in Japanese familial hypercholesterolemia (FH). OBJECTIVE We aimed to catalog the pathogenic mutations of LDL receptor gene in the 2 major Japanese FH-care centers (Kanazawa University and National Cerebral and Cardiovascular Center Research Institute), where genetic testing of FH has been performed centrally on requests from institutes all over Japan during more than past 2 decades. METHODS 796 FH subjects from 472 families who had nonsynonymous mutations in LDL

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To determine to what degree particular coping strategies mediate the association between stress and insomnia in novice nurses who are employed while continuing their education and how type of education moderate the relationships between workplace stress, coping strategies and insomnia. A descriptive cross-sectional study was performed using an online questionnaire, which was completed by 159 novice registered nurses. The questionnaire comprised four components Athens Insomnia Scale, Perceived Stress at Work (based on Perceived Stress Scale), Brief-C