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The accumulation of Zn2+, Cu2+, Fe2+, Ni2+ and Cd2+ for strain R-AmMT2 was 4, 8, 5.4, 2 and 1.6 fold of control strain suggesting the part of AmMT2 in accumulation of metals. Specially the strain R-AmMT2 managed to build up 30.7 mg per g dry body weight. The cells revealing AmMT2 had been more tolerant to hydrogen peroxide together with greater catalase (CAT) activity. To understand the mechanistic action of AmMT2 hydrogen peroxide threshold, the activity of pet int

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Treatment for patients with metastatic colorectal cancer (mCRC) typically involves multiple lines of therapy with eventual development of treatment resistance. In this single-arm, phase II study involving heavily pretreated patients, the combination of sorafenib and capecitabine yielded a clinically meaningful progression-free survival of 6.2 months with an acceptable toxicity profile. This oral doublet therapy is worthy of continued investigation for clinical use in patients with mCRC. Capecitabine (Cape) is an oral prodrug of the anti