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Attenuation of the unwanted heating of normal tissues due to eddy currents presents a major challenge in magnetic particle hyperthermia for cancer treatment. Eddy currents are a direct consequence of the applied alternating magnetic field, which is used to excite the nanoparticles in the tumor and have been shown to limit treatment efficacy in clinical trials. To overcome these challenges, this paper presents simple, clinically applicable, numerical approaches which reduce the temperature increase due to eddy currents in normal tissue an

https://www.selleckchem.com/JAK.html
To this end, crystallographic structures of HDAC6 and Hsp90 complexes will be extensively reviewed in the light of discussing binding pockets features and pharmacophore requirements and providing useful guidelines for the design of dual inhibitors. The few examples of multi-target inhibitors obtained so far, mostly based on chimeric approaches, will be summarized and put into context. Finally, the main features of HDAC6 and Hsp90 inhibitors will be compared, and ligand- and structure-based strategies potentially useful for the development of small m