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Cell adhesion molecule close homolog of L1 (CHL1) and the dopamine receptor D2 (DRD2) are associated with psychiatric and mental disorders. We here show that DRD2 interacts with CHL1 in mouse brain, as evidenced by co-immunostaining, proximity ligation assay, co-immunoprecipitation, and pull-down assay with recombinant extracellular CHL1 domain fused to Fc (CHL1-Fc). Direct binding of CHL1-Fc to the first extracellular loop of DRD2 was shown by ELISA. Using HEK cells transfected to co-express CHL1 and the short (DRD2-S) or long (DRD2-L)

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Even though the team size did not allow a statistically relevant difference, we underline that just the helical group showed no iatrogenic radial lesion. This technique deserves further interest. STANDARD OF EVIDENCE Level 3, retrospective cohort study.BACKGROUND Consensus is lacking in connection with dose and timing of tranexamic acid (TXA). The goal of this study was to see whether multiple-dose intravenous TXA further decreased blood reduction and attenuated irritation after total knee arthropla