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Rearranged during transfection (RET) gene fusions are a validated target in non-small-cell lung cancer (NSCLC). RET-selective inhibitors selpercatinib (LOXO-292) and pralsetinib (BLU-667) recently demonstrated favorable antitumor activity and safety profiles in advanced RET fusion-positive NSCLC, and both have received approval by the US Food and Drug Administration for this indication. Insights into mechanisms of resistance to selective RET inhibitors remain limited. This study was performed at five institutions. Tissue and/or cell-fr

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PRACTICAL APPLICATIONS Apigenin, apigetrin, and luteolin are understood biologically active compounds contained in celery. Acid hydrolysis could raise the biologically active substances in organic products. The study investigated the consequences of acid HCE in a mice type of atopic dermatitis. The data acquired from this research sheds light from the usage of hydrolysis solutions to enhance the biological activities of plant extracts utilized in nutraceutical sectors. © 2020 Wiley Periodicals,