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These findings demonstrate that antigens that require a free N-terminus for optimal antigen display can now be used with the RIC system, and that plant-made RICs and VLPs are highly effective vaccines targeting ZE3. Thus, the RIC platform can be more generally applied to a wider variety of antigens. INTRODUCTION Endemic measles persists in China, despite 95% reported coverage of two measles-containing vaccine doses and nationwide campaign that vaccinated 100 million children in 2010. An increasing proportion of infections now oc