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The present study compared the effects of antifibrotic medications, pirfenidone, and nintedanib, with transplantation of human umbilical mesenchymal stem cells (HUMSCs) in restoring rat pulmonary fibrosis (PF). A stable animal model was established via an intratracheal injection of 5 mg bleomycin (BLM). One single transplantation of 2.5×10 HUMSCs or initiation of daily oral nintedanib/pirfenidone administration was performed on day 21 following BLM damage. Pulmonary function examination revealed that BLM rats exhibited a