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ICAA and bifurcation angle did not predict plaque volume. In this study, CA morphology in acute stroke patients is not associated with plaque volume or composition, but age and nonplanar ICAA can predict left carotid plaque volume. In this study, CA morphology in acute stroke patients is not associated with plaque volume or composition, but age and nonplanar ICAA can predict left carotid plaque volume. Combined central and peripheral demyelination (CCPD) is a rare entity in which central and peripheral nervous system demyelination co