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he antidiabetic effect of orally administered PCC decoction, providing scientific evidence to support the clinical usage of PCC in diabetes treatment. This study was the first to comprehensively describe the pharmacokinetic profiles and hepatic disposition of alkaloids in PCC, and concluded that berberine and its metabolites contributed the most to the total hepatic gluconeogenesis inhibition by orally administered PCC. These results reveal the chemical basis for the antidiabetic effect of orally administered PCC decoction, providing sc

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26 (95% confidence interval 1.20, 1.33). Using exposure-unstratified IPCWs, the hazard ratio differed by 15 % in favor of DOACs (1.41; 95% confidence interval 1.34, 1.48). Not accounting for the different associations between the predictors and informative censoring across exposure groups may lead to misspecification of censoring weights and biased estimate on comparative effectiveness and safety.The existing cross-validated risk scores (CVRS) design has been proposed for developing and testing the efficacy of a treatment in a high-e