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Retigabine is a first-in-class potassium channel opener approved for patients with epilepsy. Unfortunately, several side effects have limited its use in clinical practice, overshadowing its beneficial effects. Multiple studies have shown that retigabine acts by enhancing the activity of members of the voltage-gated KCNQ (Kv7) potassium channel family, particularly the neuronal KCNQ channels KCNQ2-KCNQ5. However, it is currently unknown whether retigabine's action in neurons is mediated by all KCNQ neuronal channels or by only a subset. T

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Allowing your cat to go in and out of the house at will is an excellent way to keep your pet active and mentally stimulated. A flap can reduce toileting incidents by making it easier for cats to leave the home when required. Take a measurement of the door A cat flap lets your pet come and go whenever they want without you having to open the door. This is ideal to keep them inside when you're at home or away, and helps keep unwanted pests out of your house as well! It is important to measure the door to e