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We tested four configurations MPC, MPC + BPS, MS-MPC, and MS-MPC + BPS in simulation to contrast the effect of each controller module. Postprandial time in range was highest for MS-MPC + BPS 60.73 ± 25.39%, but improved with each module MPC + BPS 56.95±25.83 and MS-MPC 54.83 ± 26.00%, compared with MPC 51.79 ± 26.12%. Exposure to hypoglycemia was maintained for all controllers (time below 70 mg/dL 0.5%), and improvement came primarily from a reduction in postprandial time above range (MS-MPC + BPS 3