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Both studies comprised 15-16 healthy male and female volunteers. Itraconazole 200mg/day elevated steady-state exposure to 5mg/day balovaptan approximately 4.5-5.5-fold (Day 15 GMR [90% CI], 4.46 [4.06-4.90] for C and 5.57 [5.00-6.21] for AUC) and extended the time to steady state from ~ 5days to ~ 13-14days. Rifampicin 600mg/day resulted in ~ 90% reductions in both the C (Day 10 GMR [90% CI], 0.14 [0.12-0.15]) and AUC (0.07 [0.06-0.07]) of balovaptan 10mg/day. Time to balovaptan steady state could not be determined with rifampicin. Ther

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