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Different neoadjuvant therapy regimens are available for rectal cancer, but the relative effects are controversial. The aim of the present network meta-analysis (NMA) was to estimate the relative efficacy and safety of neoadjuvant therapies for resectable rectal cancer. MEDLINE, EMBASE and Cochrane Central Registry of Controlled Trials were searched for publications dated from 1946 up to June 2018. The present study included randomized clinical trials that compared treatments for resected rectal cancer Surgery alone, surgery preceded

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4±1.8, n=9), but substantially improved survival (93% vs. 57% DMSO). There were no differences between DMSO and PKT100 bleomycin mice in pulmonary inflammation or remodelling. However RV hypertrophy was reduced in PKT100 mice. Bleomycin decreased echocardiographic surrogates of RV systolic performance (FAC, s', which were significantly improved with PKT100. Four genes involved in RV remodelling were differentially expressed between DMSO and PKT100-treated groups. Conclusions The novel P2X7R inhibitor, PKT100, attenuates RV hypertrophy