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Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of extortionate defense mechanisms activation driven primarily by large quantities of interferon gamma. The medical presentation of HLH may have substantial overlap with other inflammatory problems. We present a cohort of patients with therapy refractory HLH referred to your center who had been found to have a simultaneous presentation of complement-mediated thrombotic microangiopathy (TMA). Twenty-three pa

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We also analysed whether co-expression of the cobalamin transporter BtuB, supports increased cobalamin incorporation into these enzymes in E. coli. We conclude that while expression in Bacillus megaterium resulted in the highest levels of cofactor incorporation, co-expression of BtuB in E. coli presents an appropriate balance between cofactor incorporation and protein yield in both cases.Adrenocorticotropic hormone (ACTH) is an old medicine derived from porcine pituitary gland that has been marketed for more than 60 years. In this s