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Introduction More than 2000 mutations have been identified since the discovery of the CFTR gene in 1989. However, only 346 mutations have been classified as cystic fibrosis (CF)-causing mutations. Due to the increasing number of mutations and poor correlation between the genotype and phenotype, there is an urgent need to determine the mutations that are pathogenic, nonpathogenic, or lead to variable symptoms. Aim The aim of the study was to present the clinical characteristics of Polish patients with rare and novel CFTR mutations, with

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Additionally, the anion-responsive nature of the present system meant that the extent of supramolecular polymerization could be regulated by introducing anions, with the resulting change in M n being readily monitored via changes in the fluorescent emission features.Entropic outlier sparsification (EOS) is proposed as a cheap and robust computational strategy for learning in the presence of data anomalies and outliers. EOS dwells on the derived analytic solution of the (weighted) expected loss minimization problem subject to Shan