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tuberculosis. This review also aims to highlight a large gap in our knowledge of pathogen physiology the interplay between metal homeostasis and central carbon metabolism, two cellular processes which are usually studied separately. Integrating metabolism and metal biology would allow the discovery of new weaknesses in bacterial physiology, leading to the development of novel and improved antibacterial therapies.As a source of therapeutic agents, heterocyclic nitrogen-containing compounds and their derivatives are still interesting a