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Median WMHv in all patients with AIS was 5.86 cm3 (interquartile range 2.18-14.61 cm3) and differed significantly across CCS subtypes (p less then 0.0001). In multivariable analysis, age, hypertension, prior stroke, smoking (all p less then 0.001), and diabetes mellitus (p = 0.041) were independent predictors of WMHv. When adjusted for confounders, patients with SAO had significantly higher WMHv compared to those with all other stroke subtypes (p less then 0.001). Conclusion In this international multicenter, hospital-based cohort of patie

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