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Adenosine A1 and/or A2A receptor antagonists hold promise for the potential treatment of neurological conditions, such as Parkinson's disease. Herein, a total of seventeen benzocycloalkanone derivatives were synthesised and evaluated for affinity towards adenosine receptors (A1 and A2A AR). The obtained results allowed for the conclusion that affinity and/or selectivity of the 2-benzylidene-1-indanone and -tetralone derivatives toward A1 and/or A2A ARs may be modulated by the nature of the substituents (either -OH, -OCH3 or morpholine)

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The Benefits of Using an Under Desk Treadmill Many people experience back pain after sitting too much, and a walking treadmill desk can ease this. It can also increase circulation, improve mental and physical well-being, and burn calories. If you are looking for an under-the-desk treadmill, pay attention to its dimensions and size. Also make sure you check the weight capacity. You'll want to think about the ease with which it can be slipped under your desk, and also if it has an attachment for y