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0001), itch VAS from 3.22 at baseline to 1.18 at week 48 (p  0.001), PGA from 2.84 at baseline to 1.30 at week 48 (p  0.0001) and DLQI from 13.09 at baseline to 6.07 at week 48 (p  0.0001). The percentage of patients who achieved PASI50 and PASI75 was 4.55% at week 4 and 59.09% at week 48 and 0% at week 4 and 22.73% at week 48, respectively. A clinical important decrease of mean PGA score was observed in all subgroups, face psoriasis, genital psoriasis and scalp psoriasis. Adverse events were predictable and manageable.