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Measles virus (MeV) bearing a single amino acid change in the fusion protein (F)-L454W-was isolated from two patients who died of MeV central nervous system (CNS) infection. This mutation in F confers an advantage over wild-type virus in the CNS, contributing to disease in these patients. Using murine ex vivo organotypic brain cultures and human induced pluripotent stem cell-derived brain organoids, we show that CNS adaptive mutations in F enhance the spread of virus ex vivo. The spread of virus in human brain organoids is blocked by an

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As we age, our bodies undergo numerous changes, many of which are driven by fluctuations in hormones. These changes can significantly affect our physical and emotional well-being, particularly for women going through menopause and men experiencing andropause. Hormone Replacement Therapy (HRT) and Bioidentical Hormone Therapy (BHT) are two treatments designed to address hormonal imbalances. If you’re seeking relief from menopause symptoms in Katy, are considering bioidentical hormone therapy in Suga