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5.3). Meta-analysis, subgroup analysis and/or descriptive analysis were performed on the included data. This study will investigate the application of fire needle in the treatment or prevention of COVID-19, and provide a high-quality synthesis to evaluate whether fire needle is an effective and safe intervention for COVID-19. PROSPERO registration number CRD 42020193703. PROSPERO registration number CRD 42020193703. Barbed suture is a novel type of suture introduced in different surgical specialties. Nevertheless, its effect in total kn

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