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001; propensity score-matched log-rank p = 0.004). This pattern was more significant in male patients (Log-rank p less then 0.001) or patients with paroxysmal AF (Log-rank p less then 0.001). Anemia (hazard ratio [HR] 1.45 [1.17-1.80], p = 0.001), left atrial diameter (HR 1.03 [1.01-1.04], p less then 0.001), a female sex (HR 1.17 [1.00-1.36], p = 0.047), and persistent AF (HR 1.58 [1.36-1.84], p less then 0.001) were independently associated with post-AFCA clinical recurrence. In the Mendelian randomization, we could not find a signifi