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OUTCOMES We prove bispecific CD19/CD22 automobile T cells could trigger sturdy cytolytic task against target cells. MRD-negative CR had been attained in 6 away from 6 enrolled clients. Autologous CD19/CD22 automobile T cells proliferated in vivo and were recognized into the bloodstream, bone tissue marrow, and cerebrospinal substance. No neurotoxicity occurred in some of the 6 clients addressed. Of note, one client had a relapse with blast cells that no longer expressed
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