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Mouse embryonic stem cells (ESCs) grown in serum-supplemented conditions are characterized by an extremely short G1 phase due to the lack of G1-phase control. Concordantly, the G1-phase-specific P53-P21 pathway is compromised in serum ESCs. Here, we provide evidence that P53 is activated upon transition of serum ESCs to their pluripotent ground state using serum-free 2i conditions and that is required for the elongated G1 phase characteristic of ground state ESCs. RNA sequencing and chromatin immunoprecipitation sequencing analyses rev

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We demonstrate the potential of photothermal deflection spectroscopy (PDS) to study the self-assembly of dye monolayers in situ. Beyond the determination of adsorption kinetics at specific wavelengths, PDS gains its strength from yielding UV-vis absorptance spectra of SAMs in situ, unaffected by scattering, from which supramolecular interactions can be deduced.A rapid and sensitive approach for enriching and extracting triazines from brown sugar samples was developed by combining magnetic dispersive solid-phase extraction and HPLC/UV. In