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In support, SSc neutrophils did not contain platelets, consistently present within CAD neutrophils. HMGB1 µPs elicit the generation of NETs, which were detected in the plasma of SSc patients only. P-selectin/PSGL-1 interaction resulted in platelet phagocytosis in vitro and influenced the µPs ability to elicit NETs, endothelial activation and migration of leukocytes through pulmonary microvasculature in mice. The clearance of activated platelets via PSGL-1 limits undesirable effects of µPs-elicited neutrophil activation. This balance is