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(3) Results A statistically significantly lower risk of CDI recurrence was observed with fidaxomicin use in the matched cohort (889 patients per treatment) using a Cox Proportional Hazards model (HR 0.67, 95% CI 0.50-0.9. (4) Conclusions Fidaxomicin was independently associated with a decreased CDI recurrence, as defined by readmission for CDI within 90 days.Antimicrobial resistance (AMR) is a major global threat to human and animal health. The use of antimicrobials in the livestock sector is considered to contribute to A