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Muscle synergy is a fundamental mechanism of motor control. Despite a number of studies focusing on muscle synergy during power grip and pinch at high-level force, relatively less is known about the functional interactions between muscles within low-level force production during precision pinch. Traditional analytical tools such as nonnegative matrix factorization or principal component analysis have limitations in processing nonlinear dynamic electromyographic signals and have confined sensitivity particularly for the low-level force pr

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Cyclic AMP is a ubiquitous second messenger used to transduce intracellular signals from a variety of Gs-coupled receptors. Compartmentalisation of protein intermediates within the cAMP signaling pathway underpins receptor-specific responses. The cAMP effector proteins protein-kinase A and EPAC are found in complexes that also contain phosphodiesterases whose presence ensures a coordinated cellular response to receptor activation events. Popeye domain containing (POPDC) proteins are the most recent class of cAMP effectors to be identified