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001) in DR (+) compared to DR (-) patients. Also, increased levels of HbA1c was significantly associated (P0.001) with decreased SOD in both subgroups (NPDR and PDR). DR severity was significantly associated with SOD and CAT in the NPDR and PDR subgroups (P0.05). Oxidative stress and decreased antioxidant defenses are associated with DR progression to its PDR stage. Oxidative stress and decreased antioxidant defenses are associated with DR progression to its PDR stage.The aim of this study was to explore association of