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German Shepherds' Protective Instinct German Shepherds are born with a protective instinct. The combination of their size and their reputation as guard dogs, together with their intimidating appearance can make them a formidable deterrent to invaders. Their protective nature can be mitigated through the right training. Early socialization and obedience are important to help them differentiate between threats and normal situations. Physical Prowess The physical prowess of the German Shepherd makes it a formidable pro

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Brain-derived neurotrophic factor (BDNF) can activate the extracellular regulated protein kinase (ERK)/cAMP response element binding protein (CRE cascade revealing an important role in antidepressant effects. Here, we studied the neuroprotective effect of baicalin (BA) in mice with chronic unpredictable mild stress (CUMS)-induced via a BDNF/ERK/CREB signaling pathway. Depression was induced via six weeks of CUMS in male ICR mice, and drug therapy was given simultaneously for the last three weeks. Cognitive dysfunctions were then ev