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R2), and 88.5±5.9 (TB1). Each method satisfied a normal brain V ≤10.0cm planning goal for targets with diameter ≤2.25cm. The mean V was 3.1cm for TB2 vs 5.5cm , 5.0cm and4.3cm , for VR1, VR2, and TB1, respectively. For a 2.5-cm diameter target, only TB2 met the V planning objective. The MRL clinical brain plans were deemed acceptable for patient treatment. The normal brain V was ≤6.0cm for all clinical targets (maximum target volume=3.51cm ). CI and CGI ranged from 1.12-1.65 and 81.2-88.3, respectively. Gamma analysis pass rates (3%