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The mRNA expression of nucleotide binding oligomerization domain receptor protein 3 (NLRP3) and Gasdermin B (GSDM was reduced in papillomas.Conclusions A younger age at diagnosis and low socioeconomic status were associated with the severity of JORRP. mRNA expression of NLRP3 and GSDMB in the papillomas of JORRP patients was significantly reduced.Abbreviation JORRP Juvenile-onset recurrent respiratory papillomatosis; RRP Recurrent respiratory papillomatosis; OSAS Obstructive sleep apnea syndrome; NLRP3 Nucleotide binding oligomerizati