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Positive rates of virulence genes vary remarkably in . Genes , and were primary ones inducing Hv- (+)-KP. IncHI1B plasmids carrying virulence genes and IncFII ones with constitute the primary combination responsible for Hv- (+)-KP. The making of Hv- (+)-KP is mostly (+)-KP acquiring another plasmid harboring virulence genes. Positive rates of virulence genes vary remarkably in K. pneumoniae. Genes iucA, p-rmpA2 and p-rmpA were primary ones inducing Hv-bla KPC(+)-KP. IncHI1B plasmids carrying virulence genes and IncFII ones with bla KPC