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p19 , primarily known as a tumor suppressor, has also been reported to play an essential role in normal development of mouse eyes. Consistently, lack of p19 has been associated with ocular defects, but the mixed background of the knockout (KO)mouse strain used raised a concern on the accuracy of the phenotypes observed in association with the targeted gene due to genetic heterogeneity. We carried out astudy to investigate into the effect of genetic background on the manifestation of p19 KO associated phenotypes. We characterized the phe

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