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A significant positive correlation between the polygenic score and a change in the plaque score (standardized β = 0.42, = 0.0235) in healthy controls with diabetes mellitus was found. Our results suggested that the combination of the and genes with a history of diabetes mellitus could exacerbate the deterioration of atherosclerosis, thereby increasing the risk of IS. Further studies are warranted to explore our results in other populations. Our results suggested that the combination of the HDAC3 and HDAC9 genes with a history of diab
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