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The role of the coagulation pathway is more significant in COVID-19 but less in HUS. Excessive complement activation appears to be a determinant of severe prognosis in both diseases. Regarding COVID-19, children have a milder symptomatology than adults, but in some cases the paediatric inflammatory multisystem syndrome (PIMS) is described.In the past years, scientific research has highlighted the presence of a new cardiovascular risk factor, the implications of which have not been sufficiently studied so far. It is different from conv