https://www.selleckchem.com/pr....oducts/17-AAG(Geldan
A chalcone series (3a-f) with electron push-pull effect was synthesized via a one-pot Claisen-Schmidt reaction with a simple purification step. The compounds exhibited strong emission, peaking around 512-567 nm with mega-stokes shift (∆λ = 93-139 nm) in polar solvents (DMSO, MeOH, and PBS) and showed good photo-stability. Therefore, 3a-f were applied in cellular imaging. After 3 h of incubation, green fluorescence was clearly brighter in cancer cells (HepG2) compared to normal cells (HEK-293), suggesting preferential accumu

https://estronechemical.com/gu....essing-nitrogen-base
They have also demonstrated efficacy in HER2-negative metastatic breast cancer tumors and advanced prostate cancer with BRCA1/2 or ATM mutations. Patients with somatic and/or germline BRCA1/2 mutations benefit more from these treatments than other customers. Nowadays, the diagnosis of HRD is basically considering germline genetic evaluation, that will be performed after an in-person genetic counseling session, also for