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Here, we detail the cellular function of tumor suppressors essential in DNA damage repair pathways, present the mechanisms of action of inhibitors used to create synthetic lethality in BRCA carriers, and review the major molecular sources of drug resistance. Finally, we present examples of the many strategies being developed to circumvent drug resistance. To obtain public support for the active disinvestment (i.e. policy decision to stop reimbursement) of healthcare interventions, it is important to have insight in what the public think

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What to Look For in a 3 Wheel Electric Scooter This is a great option to consider if you're in search of an electric 3 wheel scooter that gives you the freedom you desire. It has a range of 43 miles and is able to be driven effortlessly up ramps or sidewalks. It starts with a push of the button and doesn't require maintenance or fuel. It also has a safe storage container that can be used to store batteries for backup. Safety A 3-wheel electric scooter can provide an efficient and safe method of transport for peo