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Complete reperfusion (TICI 3) after the first thrombectomy attempt or first pass effect (FPE) is associated with best clinical outcomes in large-vessel occlusion (LVO) acute ischemic stroke. While endovascular therapy techniques have improved substantially, FPE remains low (24-30%), and new methods to improve reperfusion efficiency are needed. In a prospective observational cohort study, 40 consecutive patients underwent cyclical aspiration thrombectomy using CLEAR Aspiration System (Insera Therapeutics Inc., Dallas, TX). Primary outcom

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