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Fenestration of the baffle/conduit is believed to reduce pleural effusion following the Fontan operation. However, equivocal results have been observed with or without fenestration. This study aims to evaluate the efficacy of fenestration on the amount and duration of pleural effusion following the Fontan operation. About 40 patients undergoing extracardiac Fontan (ECF) were randomized into two groups one with fenestration (ECF-F; n = 2 or without fenestration (ECF-NF; n = 2. Primary outcome was the amount and duration of pleural e