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Tracheal trauma is an uncommon but potentially serious cause of airway injury in children. Presentation may be acute in cases of blunt or penetrating trauma, or delayed in cases of chronic irritation or indwelling endotracheal tubes. Symptoms include dyspnea, progressive respiratory distress, neck and chest swelling and ecchymosis, and dysphonia. Workup is pursued as allowed by the patient's clinical status and may include plain radiography, computed tomography, and endoscopy. Accuracy and efficiency of diagnosis is paramount for tho

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The baseline renal graft level (E, maximum effect (Emax), AUC achieving 50% of the maximum effect (EAUC5, and nephrotoxicity slope were estimated as 12.9 mL/min/1.73 m2, 50.7 mL/min/1.73 m2, 1740 ng.h/mL, and 0.00033, respectively. Hemoglobin level was identified as a significant covariate affecting the E0. The model discerned acute rejection from nephrotoxicity in 19/24 cases. A time-dissociated PKPD model successfully described a large number of observations and was used to develop an online tool to predict renal graft response.