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Hostility is associated with greater risk for cardiac disease, cardiac events and dysrhythmias. Investigators have reported equivocal findings regarding the association of hostility with acute coronary syndrome (ACS) recurrence and mortality. Given mixed results on the relationship between hostility and cardiovascular outcomes, further research is critical. The aim of our study was to determine whether hostility was a predictor of ACS recurrence and mortality. We performed a secondary analysis of data ( = 2321) from a large