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47, 95% confidence interval (CI) 0.38-0.57), whereas those who received no treatment had 1.6 times higher odds of experiencing APOs. One common risk factor across different APOs was high levels of log2-transformed toluidine red unheated serum test (TRUST) titers before treatment (OR 1.14, 95% CI 1.10-1.19). China-recommended treatment was effective in reducing APOs for those with TRUST ≥ 1 8 (OR 0.21, 95% CI 0.14-0.29) and those with TRUST less then 1 8 (OR 0.62, 95% CI 0.50-0.77). Conclusions Syphilis-seropositive women receiving Chi