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Research indicates that Internet use positively influences cognitive functioning in later life, but we do not know the behavioral pathways that explain this association. This study explored the role of participation in activities as a potential mediator of the relationship between Internet use and cognitive functioning over a 4-year period. We analyzed representative data from the Survey of Health, Ageing and Retirement in Europe (SHARE). The sample included 8353 European participants between 50 and 97 years of age. We used data from 201

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Herein, we illustrate the evidences that support the role played by EPCs dysfunction in SLE. Subsequently, we discuss about the hypothesis that the Ca2+ handling machinery is compromised in SLE-derived ECFCs and MACs, thereby resulting in their reduced pro-angiogenic activity. Finally, we speculate about the proposal to exploit intracellular Ca2+ signaling to improve ECFCs' reparative phenotype and suggest this strategy as a new approach to treat SLE patients.Fertility is an important economic trait in livestock and poultry that rel