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56 %, 2.54 %] correspond to high confidence of 0.95. An in-vivo intracranial pressure (ICP) measurement experiment on the rat brain has been conducted to further validate the feasibility and effectiveness of the designed sensor. The macroscopic singlet oxygen (MSO) model for quantifying the light-induced singlet oxygen (1O2) always contain a set of nonlinear dynamic equations and therefore are generally difficult to be applied. This work was devoted to analyze and simplify this dynamic model. Firstly, the nonlinearity of the MSO model
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