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Mitochondria play vital role in regulating the cellular energetics and metabolism. Further, it is a signaling hub for cell survival and apoptotic pathways. One of the key determinants that calibrate both cellular energetics and survival functions is mitochondrial calcium (Ca2+) dynamics. Mitochondrial Ca2+ regulates three Ca2+-sensitive dehydrogenase enzymes involved in tricarboxylic acid cycle (TCA) cycle thereby directly controlling ATP synthesis. On the other hand, excessive Ca2+ concentration within the mitochondrial matrix elevates mi

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Bi Fold Door Repair - How to Fix Leaning Doors Without Removing the Hinges Bi fold doors are a fashionable way to make your home more spacious and connect indoor and outdoor spaces. But, as with every other door system, they need to be properly maintained to function correctly. This can be accomplished by cleaning and lubricating all mechanisms, including the lock, to ensure they function properly. This will prevent problems that could cause them to break or become out of alignment. How to f